Regulation of pancreatic beta-cell function by adipocytes / 生理学报
Acta Physiologica Sinica
; (6): 247-252, 2007.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-258661
Responsible library:
WPRO
ABSTRACT
Adipokines, the bioactive factors derived mainly from adipocytes, regulate pancreatic beta-cell function including insulin secretion, gene expression and apoptosis. In this review, we propose that adipokines influence beta-cell function through three interdependent pathways. The first is through regulating lipid and glucose metabolism in beta-cells. The second implicates the change of ion channel opening and closing in beta-cells. The third pathway is via the modification of insulin sensitivity of beta-cells. The endocrine function of adipocytes is dynamic, and the secretion of various adipokines changes under different metabolic conditions. During the progression from the normal state to obesity and to type 2 diabetes, adipokines contribute to the occurrence and development of beta-cell dysfunction in type 2 diabetes.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Adipocytes
/
Leptin
/
Diabetes Mellitus, Type 2
/
Insulin-Secreting Cells
/
Adiponectin
/
Lipid Metabolism
/
Glucose
/
Insulin
Limits:
Animals
/
Humans
Language:
English
Journal:
Acta Physiologica Sinica
Year:
2007
Document type:
Article