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Association Between Serum Uric Acid and Prevalence of Type 2 Diabetes Diagnosed using HbA1c Criteria Among Chinese Adults in Qingdao, China / 生物医学与环境科学(英文)
Article in English | WPRIM (Western Pacific) | ID: wpr-258864
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine whether elevated serum uric acid (UA) levels are associated with type 2 diabetes diagnosed using HbA1c levels among Chinese adults.</p><p><b>METHODS</b>We conducted two population-based cross-sectional studies in Qingdao in China in 2006 and 2009. A total of 6894 (39.4% men) subjects aged 35-74 years were included in the data analysis. Newly diagnosed diabetes was defined as HbA1c level of ⋝6.5%, and prediabetes was classified as HbA1c level between 5.7% and 6.4% according to the International Diabetes Federation criteria. Multivariate logistic regression was employed to assess the association between UA and prevalence of type 2 diabetes defined using Glycated hemoglobin A1c (HbA1c) levels.</p><p><b>RESULTS</b>Subjects with prediabetes had higher UA levels than those with normal glucose tolerance, newly diagnosed diabetes, and known diabetes, with corresponding values of 325.1 (82.5) µmol/L, 310.9 (84.2) µmol/L, 291.3 (81.7) µmol/L, 305.2 (83.6) µmol/L, respectively (P<0.001 for all comparisons). Binary logistic regression analysis showed that UA was a possible predictor for the prevalence of type 2 diabetes diagnosed using HbA1c levels, and the second quartile of UA levels had a higher odds ratio (OR 4.088; 95% CI 2.900-5.765) for HbA1c than the other quartiles after adjusting for age, body mass index, sex, marital status, education, income, alcohol consumption, smoking, and cardiometabolic parameters.</p><p><b>CONCLUSION</b>Serum UA is significantly associated with type 2 diabetes diagnosed using HbA1c levels, independent of other cardiometabolic parameters.</p>
Subject(s)

Full text: Available Database: WPRIM (Western Pacific) Main subject: Uric Acid / Blood / Glycated Hemoglobin / China / Epidemiology / Prevalence / Cross-Sectional Studies / Asian People / Diabetes Mellitus, Type 2 / Metabolism Type of study: Diagnostic study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Biomedical and Environmental Sciences Year: 2015 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Uric Acid / Blood / Glycated Hemoglobin / China / Epidemiology / Prevalence / Cross-Sectional Studies / Asian People / Diabetes Mellitus, Type 2 / Metabolism Type of study: Diagnostic study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Biomedical and Environmental Sciences Year: 2015 Document type: Article
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