Association Between Serum Uric Acid and Prevalence of Type 2 Diabetes Diagnosed using HbA1c Criteria Among Chinese Adults in Qingdao, China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 884-893, 2015.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-258864
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine whether elevated serum uric acid (UA) levels are associated with type 2 diabetes diagnosed using HbA1c levels among Chinese adults.</p><p><b>METHODS</b>We conducted two population-based cross-sectional studies in Qingdao in China in 2006 and 2009. A total of 6894 (39.4% men) subjects aged 35-74 years were included in the data analysis. Newly diagnosed diabetes was defined as HbA1c level of ⋝6.5%, and prediabetes was classified as HbA1c level between 5.7% and 6.4% according to the International Diabetes Federation criteria. Multivariate logistic regression was employed to assess the association between UA and prevalence of type 2 diabetes defined using Glycated hemoglobin A1c (HbA1c) levels.</p><p><b>RESULTS</b>Subjects with prediabetes had higher UA levels than those with normal glucose tolerance, newly diagnosed diabetes, and known diabetes, with corresponding values of 325.1 (82.5) µmol/L, 310.9 (84.2) µmol/L, 291.3 (81.7) µmol/L, 305.2 (83.6) µmol/L, respectively (P<0.001 for all comparisons). Binary logistic regression analysis showed that UA was a possible predictor for the prevalence of type 2 diabetes diagnosed using HbA1c levels, and the second quartile of UA levels had a higher odds ratio (OR 4.088; 95% CI 2.900-5.765) for HbA1c than the other quartiles after adjusting for age, body mass index, sex, marital status, education, income, alcohol consumption, smoking, and cardiometabolic parameters.</p><p><b>CONCLUSION</b>Serum UA is significantly associated with type 2 diabetes diagnosed using HbA1c levels, independent of other cardiometabolic parameters.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Uric Acid
/
Blood
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Glycated Hemoglobin
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China
/
Epidemiology
/
Prevalence
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Cross-Sectional Studies
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Asian People
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Diabetes Mellitus, Type 2
/
Metabolism
Type of study:
Diagnostic study
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Observational study
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Prevalence study
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Prognostic study
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Risk factors
Limits:
Adult
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Aged
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Female
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Humans
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Male
Country/Region as subject:
Asia
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2015
Document type:
Article