Clinical Manifestations of Optic Nerve Hypoplasia
Journal of the Korean Ophthalmological Society
; : 1465-1471, 2006.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-25892
Responsible library:
WPRO
ABSTRACT
PURPOSE:
To estimate the baseline demographic and ocular characteristics of patients with optic nerve hypoplasia (ONH), and to analyze the different features and frequency of coexistent CNS abnormalities and pituitary hormone deficiency.METHODS:
The authors reviewed the medical records of the patients who were seen between January 1988 and July 2005. Eyes with disc-to-macula / disc diameter ratio of 3.0 or more were eligible. The study comprised 70 patients (45 male, 25 female) and the average age was 6.4 years.RESULTS:
Ocular manifestations included strabismus and nystagmus in 60 patients (85.7%) and 23 patients (32.9%), respectively. Eighty-four patients (87.5%) had visual acuity of 0.3 or less. Neuroradiologic examination of 27 patients revealed two with septo-optic dysplasia, two with pituitary hypoplasia, one with an absence of corpus callosum, one with diffuse encephalomalacia, one with a cerebral infarction in the right cerebral hemisphere, and one with a cerebellar injury. Of 12 patients who had undergone a clinical laboratory test, two had isolated growth hormone deficiency, one had a combined deficiency of growth hormone and gonadotropin and one had a combined deficiency of growth hormone and thyrotropin.CONCLUSIONS:
Ocular features frequently associated with ONH are strabismus, nystagmus and poor vision. ONH is often associated with a wide variety of central nervous system abnormalities and pituitary hormone defect, so a systematic approach to patients with ONH is always recommended.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Optic Nerve
/
Growth Hormone
/
Thyrotropin
/
Visual Acuity
/
Central Nervous System
/
Cerebral Infarction
/
Medical Records
/
Strabismus
/
Septo-Optic Dysplasia
/
Dwarfism, Pituitary
Limits:
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2006
Document type:
Article