Antipruritic mechanisms of pimecrolimus cream for facial dermatitis in adult women patients / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 27-30, 2009.
Article
in Zh
| WPRIM
| ID: wpr-259082
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the antipruritic mechanisms of pimecrolimus cream for women facial dermatitis.</p><p><b>METHODS</b>Topical pimecrolimus cream 1% was applied in 52 women patients with facial dermatitis. The Investigators Global Assessment (IGA) score, severity of pruritus (SP) scores, and a basic syntax and molecular substrate (molecular psychophysics) of nociception and pruriception established by temperature-sensitive transient receptor potential (TRP) channels were used to evaluate the clinical signs, severity of pruritus, and skin sensory phenomenon.</p><p><b>RESULTS</b>The IGA scores at day 1 and 4 of treatment and the SP score at day 1, 4, and 11 of treatment were significantly lower than the baseline scores before treatment (P < 0.05). Among these 52 patients, 28 (53.8%) showed positive capsaicin-like response (i.e., burning with consequent rapid amelioration of pruritus) at the application sites, 12 (23.1%) showed camphor-like response (i.e., warming with consequent rapid amelioration of pruritus), and 12 (23.1%) showed negative capsaicin-like response or negative camphor-like response.</p><p><b>CONCLUSIONS</b>Treatment with pimecrolimus cream 1% can rapidly and effectively improve the signs and symptoms of facial dermatitis in adult women patients. Pimecrolimus cream 1% may act on the transient potential vanilloid 1 (TRPV1) receptor in the skin sensory afferents to induce capsaicin-like response or camphor-like response and then desensitizes TRPV1 and rapidly inhibits or alleviate itching.</p>
Full text:
1
Database:
WPRIM
Main subject:
Pruritus
/
Administration, Topical
/
Tacrolimus
/
Dermatitis
/
Drug Therapy
/
Face
/
Antipruritics
Limits:
Adolescent
/
Adult
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Female
/
Humans
Language:
Zh
Journal:
Acta Academiae Medicinae Sinicae
Year:
2009
Document type:
Article