Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 213-215, 2010.
Article
in Zh
| WPRIM
| ID: wpr-259306
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of 14-3-3 sigma and heat shock protein 27 (HSP27) in colorectal carcinoma(CRC) tissue and its clinical significance.</p><p><b>METHODS</b>The expression of 14-3-3 sigma and HSP27 was detected by immunohistochemical staining in 50 pathologically verified CRC cases. The association of clinical data with 14-3-3 sigma and HSP27 expression was examined.</p><p><b>RESULTS</b>The positive expression rate of 14-3-3 sigma was 10% in normal control mucosa and 58% in CRC tissue (P<0.01). The positive expression rate of HSP27 was 16% in normal control mucosa and 54% in CRC tissue (P<0.01). No correlation between 14-3-3 sigma and HSP27 expression was found in CRC tissue (P>0.05). The expression of 14-3-3 sigma was associated with patient age, tumor diameter and lymph node metastasis (LNM) (P<0.05), but not with gender, tumor differentiation or serous membrane invasion (P>0.05). The expression of HSP27 was associated with LNM (P<0.05), but not with gender, age, differentiation, tumor diameter or serous membrane invasion (P>0.05).</p><p><b>CONCLUSION</b>The abnormal expression of 14-3-3 sigma and HSP27 is significantly associated with LNM in CRC.</p>
Full text:
1
Database:
WPRIM
Main subject:
Pathology
/
Colorectal Neoplasms
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Biomarkers, Tumor
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14-3-3 Proteins
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Exonucleases
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Exoribonucleases
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HSP27 Heat-Shock Proteins
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Lymphatic Metastasis
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Metabolism
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Neoplasm Proteins
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2010
Document type:
Article