Effect of human papilloma virus infection status on the prognosis of localized stage head and neck squamous cell carcinomas in different ethnic groups of Xinjiang / 中华口腔医学杂志
Chinese Journal of Stomatology
; (12): 742-745, 2015.
Article
in Zh
| WPRIM
| ID: wpr-259450
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To discuss the effect of limited head and neck squamous cell carcinomas human papillomavirus(HPV) infection status on the prognosis in different nationalities of Xinjiang.</p><p><b>METHODS</b>The clinical data of 149 cases of head and neck squamous cell carcinoma from Uighur, Han and Kazak was analyzed. The HPV16/18 infection and viral load was examined.The prognosis was analyzed by cox multiIvar-Iate model. The effect of HPV infection status on prognosis was evaluated.</p><p><b>RESULTS</b>In this study, Oropharyngeal HPV infection rate was 35.0%, followed by hypopharynx 30.0%, oropharyx was 16.0%. The overall survival rate of 3 years and 5 years was 66.4%, and 39.2% respectively. The clinical stage,N stage and HPV were influencing factors for the prognosis of patients with head and neck squamous cell carcinoma (P< 0.05). N stage and HPV were independent prognostic factors for the prognosis of patients with head and neck squamous cell carcinoma (P< 0.05).</p><p><b>CONCLUSIONS</b>There is a high rate of HPV infection in oropharynx in head and neck cancer. HPV positive is a protective factor for the prognosis of head and neck cancer, and the risk of death in patients with HPV was 3/5 lower than that of HPV negative patients. HPV viral load may be positively related to the total survival rate. N stage is a risk factor for the prognosis of head and neck cancer. Different nationalities have little influence on prognosis.</p>
Full text:
1
Database:
WPRIM
Main subject:
Pathology
/
Prognosis
/
Time Factors
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Virology
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Carcinoma, Squamous Cell
/
Ethnicity
/
Proportional Hazards Models
/
China
/
Survival Rate
/
Mortality
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Stomatology
Year:
2015
Document type:
Article