Research on phytoestrogenic effect of formononetin / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3060-3064, 2010.
Article
in Zh
| WPRIM
| ID: wpr-260687
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Research on the phytoestrogenic effect and its possible mechanism of formononetin.</p><p><b>METHOD</b>To evaluate the estrogenic effect and mechanisms of formononetin through the test of its influence on proliferation and ER subtype expression of T47D cells.</p><p><b>RESULT</b>The proliferation rates of T47D cells treated with 1 x 10(-7) -1 x 10(-6) mol x L(-1) formononetin were not increased. On the influence of ICI182, 780, the proliferation rates of T47D cells treated with 1 x 10(-7) 1 x 10(-6) mol x L(-1) formononetin were decreased. Formonenetin could induce the augment of ERalpha expression significantly of T47D.</p><p><b>CONCLUSION</b>Formonenetin has phytoestrogenic effect Formonenetin can not accelerate ER(+) T47D cell proliferation. But the expression level of ERalpha subtype in T47D cells change significantly with certain concentrations of formonenetin.</p>
Full text:
1
Database:
WPRIM
Main subject:
Pharmacology
/
Breast Neoplasms
/
Receptors, Estrogen
/
Cell Line, Tumor
/
Phytoestrogens
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Cell Proliferation
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Drug Therapy
/
Genetics
/
Isoflavones
/
Metabolism
Limits:
Female
/
Humans
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2010
Document type:
Article