Levels of surfactant proteins A and D in bronchoalveolar lavage fluid of children with pneumonia and their relationships with clinical characteristics / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 386-390, 2016.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-261223
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the levels of pulmonary surfactant proteins A and D (SP-A, SP-D) in bronchoalveolar lavage fluid (BALF) of children with pneumonia, and to explore their relationships with clinical characteristics.</p><p><b>METHODS</b>Thirty-five children with pneumonia were enrolled in this study. Differential cell counts were obtained by Countstar counting board. The levels of SP-A and SP-D in BALF were detected using ELISA.</p><p><b>RESULTS</b>In children with pneumonia, SP-D levels were significantly higher than SP-A levels (P<0.001). SP-D levels were negatively correlated with the neutrophil percentage in BALF (r(s)=-0.5255, P<0.01). SP-D levels in BALF in children with increased blood C-reactive protein levels (>8 mg/L) were significantly lower than in those with a normal level of C-reactive protein (P<0.05). Compared with those in children without wheezing, SP-D levels in children with wheezing were significantly lower (P<0.01). There was no correlation between SP-A levels and clinical characteristics.</p><p><b>CONCLUSIONS</b>SP-D levels in BALF are significantly higher than SP-A levels, and have a certain correlation with clinical characteristics in children with pneumonia. As a protective factor, SP-D plays a more important role than SP-A in regulating the immune and inflammatory responses.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pneumonia
/
C-Reactive Protein
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Enzyme-Linked Immunosorbent Assay
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Bronchoalveolar Lavage Fluid
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Chemistry
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Pulmonary Surfactant-Associated Protein A
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Pulmonary Surfactant-Associated Protein D
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Metabolism
Limits:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2016
Document type:
Article