Animal models of Peyronie's disease: An update / 中华男科学杂志
National Journal of Andrology
; (12): 446-449, 2016.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-262330
Responsible library:
WPRO
ABSTRACT
Peyronie's disease is characterized by local fibrosis of the tunica albuginea and relatively rare clinically. Few relevant basic researches could be retrieved, which might be attributed to the absence of a robust animal model of the disease as well as to its rareness. At present, some animal models available for Peyronie's disease have their own merits and demerits. TGF-β1-induced and Fibrin-induced models are lack of penile curvature and calcification/ossification. A surgical model might be established for the acute phase of the disease. The characteristic of a widespread fibrotic process involving many organs in the spontaneous model is quite different from that of human Peyronie's disease. Therefore, choosing the right model is essential for researches. This paper presents an overview of the animal models of Peyronie's disease, meant to provide some reference for the basic research of the disease.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Penile Induration
/
Penis
/
Fibrosis
/
Fibrin
/
Disease Models, Animal
/
Transforming Growth Factor beta1
Type of study:
Prognostic study
Limits:
Animals
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2016
Document type:
Article