Changes of cell immunophenotypes after transformation from myeloproliferative disorders into acute myeloid leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 636-641, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-263333
Responsible library:
WPRO
ABSTRACT
Some cases of myeloproliferative disorders (MPD) could be transformed into acute myeloid leukemia (AML), but the cell differentiation process of MPD into AML has not yet been observed in vivo. This study was aimed to reveal this differentiation process. The flow cytometry was used to analyse the immunophenotype of differentiated cells of 2 MPD cases who developed into AML in a short time. The reports showed that the different MPD-AML subclones are presented when the MPD cells that proliferate slowly in vivo become the AML blast cells that proliferate rapidly. It is concluded that understanding the process of MPD crisis will help the MPD-AML early diagnosis and treatment.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Leukemia, Myeloid, Acute
/
Cell Transformation, Neoplastic
/
Immunophenotyping
/
Flow Cytometry
/
Myeloproliferative Disorders
Type of study:
Screening study
Limits:
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2012
Document type:
Article