Analysis of HLA-DRB1 allele polymorphism in the Fujian Han nationality population of China / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the HLA-DRB1 allele polymorphism in Fujian Han nationality population.</p><p><b>METHODS</b>Six hundred and twenty individual samples collected from unrelated Fujian Han population were subjected to genotyping using oligonucleotide microarray technique. And the allele frequencies of HLA-DRB1 were calculated and compared with other populations.</p><p><b>RESULTS</b>Fourteen HLA-DRB1 alleles of Fujian Han population were detected. The gene frequencies ordered from high to low were HLA-DRB1*9, 12, 15, 4, 8 respectively.</p><p><b>CONCLUSION</b>The HLA-DRB1 distribution of Fujian Han population shares some genetic characters with southern Chinese Han populations, but these characters differ from northern Chinese populations.</p>