Polymorphism of vitamin D receptor gene Fok I in Mongolian population of China / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the polymorphism distribution of vitamin D receptor (VDR) gene Fok I in Mongolian population of China.</p><p><b>METHODS</b>Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to analyze three genotypes FF, Ff and ff in the start codon of VDR gene (Fok I) in unrelated normal healthy Mongolian individuals of China.</p><p><b>RESULTS</b>In the population, we obtained the allelic frequencies of 57% and 43% for (F) and (f) allele and the percentage of genotypes FF, Ff and ff to be 31%, 52%, and 17% respectively.</p><p><b>CONCLUSION</b>The polymorphism frequency and distribution of this VDR gene Fok I in Mongolian population of China exhibit its own characteristics.</p>