Effect of resuscitation after selective cerebral ultraprofound hypothermia on expressions of nerve growth factor and glial cell line-derived neurotrophic factor in the brain of monkey / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 150-154, 2008.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-264683
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) in monkeys of resuscitation after selective cerebral ultraprofound hypothermia and blood flow occlusion.</p><p><b>METHODS</b>The monkeys were immediately removed brain after death in operation of group A (identical temperature perfusion group) and group B (ultraprofound hypothermia perfusion group). Immunohistochemical technique was used to determine frontal cellular expression of NGF and GDNF. Statistics were analyzed by ANOVA analyses with significance level at P < 0.05.</p><p><b>RESULTS</b>The expressions of NGF and GDNF in the group B were significantly higher than those in the group A (P < 0.05).</p><p><b>CONCLUSION</b>NGF and GDNF increased significantly in the monkeys of resuscitation after selective cerebral ultraprofound hypothermia and blood flow occlusion. It may be a protective mechanism for neuron survival and neural function recovery.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Resuscitation
/
Brain
/
Reperfusion Injury
/
Up-Regulation
/
Cell Survival
/
Cerebrovascular Circulation
/
Cerebrovascular Disorders
/
Cytoprotection
/
Recovery of Function
Limits:
Animals
Language:
English
Journal:
Neuroscience Bulletin
Year:
2008
Document type:
Article