Evaluation of targeting property for Kuikang colon targeted pellets / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1556-1604, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-264898
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate colon targeting characteristic of Kuikang colon targeted pellets (KCP) with determination of residual baicalin and baicalein concentration in gastrointestinal tract (GIT).</p><p><b>METHOD</b>The baicalin and baicalein were assayed by HPLC. The recovery differences of the drug between KCP and conventional pellets from GIT were investigated, three and six hours after administration.</p><p><b>RESULT</b>The baicalin recovery of KCP (70%) from rat GIT was higher than that of CP (about 20%). Most of KCP were intact at 3 h after oral administration, and distributed in lower ileum. It indicated that release site of KCP was in lower ileum and colon. Six hours later, a small amount of baicalin was recovered in intestime, which showed that the release of baicalin from KCP was complete.</p><p><b>CONCLUSION</b>The determination of residual baicalin in rat GIT was feasibility for evaluating KCP. The result confirmed KCP of colon targeting property.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Flavonoids
/
Drugs, Chinese Herbal
/
Logistic Models
/
Drug Delivery Systems
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Rats, Wistar
/
Colon
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Flavanones
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Drug Implants
/
Ileum
/
Metabolism
Type of study:
Prognostic study
/
Risk factors
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2008
Document type:
Article