Expression of MMP-2 and TIMP-1 in renal tissues of patients with chronic active antibody-mediated renal graft rejection / 南方医科大学学报
Journal of Southern Medical University
; (12): 2048-2051, 2011.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-265721
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of matrix metalloprotein-2 (MMP-2) and tissue inhibitor of metallopeptidase inhibitor-1 (TIMP-1) in the renal allografts of patients with chronic active antibody-mediated rejection (ABMR), and explore their role in the pathogenesis of ABMR.</p><p><b>METHODS</b>Immunohistochemistry and computer-assisted image analysis were used to detect the expression of MMP-2 and TIMP-1 in the renal allografts of 46 patients with interstitial fibrosis and tubular atrophy (IF/TA), with 15 normal renal tissue specimens as the control. The association of MMP-2 and TIMP-1 with the pathological grade of IF/TA in ABMR was analyzed.</p><p><b>RESULTS</b>The expressions of MMP-2 and TIMP-1 significantly increased in the renal tissues of the patients as compared with the normal renal tissues (P<0.05). MMP-2 expression tended to decrease, while TIMP-1 and serum creatinine increased with the pathological grades of IF/TA (P<0.05). In IF/TA group, the expression of TIMP-1 was positively correlated to serum creatinine level (r=0.718, P=0.00<0.05).</p><p><b>CONCLUSION</b>Abnormal expressions of MMP-2 and TIMP-1 can promote the development of renal fibrosis in chronic ABMR.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Peptide Fragments
/
Fibrosis
/
Complement C4b
/
Kidney Transplantation
/
Tissue Inhibitor of Metalloproteinase-1
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Matrix Metalloproteinase 2
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Allergy and Immunology
/
Genetics
/
Graft Rejection
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2011
Document type:
Article