Studies on formulations of Panax notoginsenosides for intranasal administration / 药学学报
Acta Pharmaceutica Sinica
; (12): 859-862, 2003.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-266567
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To develop high bioavailability preparations without irritation for Panax notoginsenosides.</p><p><b>METHODS</b>The effects of some additives such as microcrystalline cellulose, beta-cyclodextrin and hydroxypropyl cellulose on drug in the preparations were examined.</p><p><b>RESULTS</b>Saponins of Panax notoginseng (PNS) was absorbed in rabbits more when administered intranasally than through other routines, and the formulations including MCC both gave high bioavailability and low irritation.</p><p><b>CONCLUSION</b>Bioavailability of Panax notoginsenosides can be increased through changing routine of administration and formulations.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Permeability
/
Bufo bufo
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Administration, Intranasal
/
Drug Carriers
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Pharmacokinetics
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Biological Availability
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Cellulose
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Chemistry
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Drug Delivery Systems
/
Cyclodextrins
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2003
Document type:
Article