Epstein-Barr Virus Associated Hemophagocytic Syndrome after Scrub Typhus Infection / 감염과화학요법
Infection and Chemotherapy
; : 330-333, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-26684
Responsible library:
WPRO
ABSTRACT
There have been a small number of cases of scrub typhus-associated hemophagocytic syndrome (HPS), most of which were treated successfully using adequate antibiotics. Here, we report a case of Epstein-Barr virus (EBV)-associated HPS after scrub typhus infection that was not improved using antirickettsial treatment. A 73-year-old male who had been diagnosed with scrub typhus according to an eschar and a positive serology was transferred to our institution because of a persistent fever despite 7-day doxycycline therapy. Physical and laboratory data showed hepatosplenomegaly, bicytopenia, hyperferritinemia, and hypofibrinogenemia. A bone marrow examination (BM) revealed hypercellular marrow with hemophagocytosis and histiocyte infiltration. EBV was detected in BM aspirates using polymerase chain reaction. After a diagnosis of HPS was made, the patient was treated successfully using high-dose steroids.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Steroids
/
Bone Marrow
/
Bone Marrow Examination
/
Scrub Typhus
/
Polymerase Chain Reaction
/
Doxycycline
/
Herpesvirus 4, Human
/
Epstein-Barr Virus Infections
/
Diagnosis
/
Lymphohistiocytosis, Hemophagocytic
Type of study:
Diagnostic study
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Infection and Chemotherapy
Year:
2016
Document type:
Article