Association between Body Mass Index and Sputum Culture Conversion among South Korean Patients with Multidrug Resistant Tuberculosis in a Tuberculosis Referral Hospital / 감염과화학요법
Infection and Chemotherapy
; : 317-323, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-26686
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Multidrug-resistant tuberculosis (MDR-TB) is an important global health problem. Furthermore, the time to identify a positive sputum culture is an important risk factor for the spread of tuberculosis, and several factors can predict a prolonged time to culture conversion. Moreover, the relationship between poor nutritional status and infectious disease is clearly established. Therefore, the present study aimed to investigate the association between body mass index (BMI) and sputum culture conversion within 3 months among patients with MDR-TB. MATERIALS ANDMETHODS:
We retrospectively evaluated 218 patients with MDR-TB who were treated at a large tuberculosis referral hospital in South Korea between January 2005 and December 2010. The outcome of interest was defined as sputum culture conversion within 3 months, and we analyzed the association between BMI and this outcome.RESULTS:
Among the 218 patients, 53 patients (24.3%) had a low BMI (<18.5 kg/m²). In the multivariate Cox proportional-hazards regression analysis, failure to achieve sputum culture conversion within 3 months was independently associated with having a low BMI (hazard ratio [HR] 1.741, 95% confidence interval [CI] 1.006–3.013; P = 0.047) and a positive sputum smear at the initiation of therapy (HR 8.440, 95% CI 1.146–62.138, P = 0.036).CONCLUSION:
Low BMI (<18.5 kg/m²) was an independent risk factor for failure to achieve sputum culture conversion within 3 months among patients with MDR-TB.
Full text:
Available
Health context:
SDG3 - Target 3.8 Achieve universal access to health
/
SDG3 - Health and Well-Being
/
Neglected Diseases
Health problem:
Delivery Arrangements
/
Target 3.8 Achieve universal access to health
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Neglected Diseases
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Tuberculosis
Database:
WPRIM (Western Pacific)
Main subject:
Referral and Consultation
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Sputum
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Tuberculosis
/
Body Mass Index
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Global Health
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Nutritional Status
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Communicable Diseases
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Retrospective Studies
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Risk Factors
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Tuberculosis, Multidrug-Resistant
Type of study:
Etiology study
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Observational study
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Prognostic study
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Risk factors
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Infection and Chemotherapy
Year:
2016
Document type:
Article