Effect of different compatibility of tetramethylpyrazine on its pharmacokinetics in vivo / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1311-1314, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-267026
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the pharmacokinetics of single administration and different compatibility of tetramethylpyrazine (TMP) in rats.</p><p><b>METHOD</b>Thirty two Sprague-Dawley rats were randomly divided into 4 groups the TMP (30 mg x kg(-1)) group, the TMP+FA (30 mg x kg(-1) + 50 mg x kg(-1)) group, the TMP+TET (30 mg x kg(-1) mg x kg(-1)) group and the TMP+FA+TET (30 mg x kg(-1) + 50 mg x kg(-1) + 20 mg x kg(-1)) group. After the oral administration, their blood samples were collected to detect plasmas concentrations by HPLC method and to calculate pharmacokinetic parameters DAS 2.0 program.</p><p><b>RESULT</b>In compatibility with FA, AUC(0-t), Cmax and Tmax showed no significant difference with the single administration of TMP, but t(1/2) and MRT,, were obviously longer than the single administration. In compatibility with TET and FA + TET, AUC (0-t), Cmax and Tmax showed significant increase than the single administration of TMP, whereas t(1/2) and MRT0, did not notably vary from the single administration.</p><p><b>CONCLUSION</b>FA can prolong TMP's action time in rats, and TET can accelerate TMP's absorption in rats.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pyrazines
/
Pharmacokinetics
/
Random Allocation
/
Chromatography, High Pressure Liquid
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Rats, Sprague-Dawley
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Coumaric Acids
/
Diterpenes
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Drug Interactions
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2012
Document type:
Article