Regulation of the self-renewal and differentiation of spermatogonial stem cells / 中华男科学杂志
National Journal of Andrology
; (12): 963-967, 2013.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-268023
Responsible library:
WPRO
ABSTRACT
Spermatogonial stem cells (SSCs) play an important role in spermatogenesis and have a unique mode of replication. A single SSC can produce two differentiating cells, or one stem cell and one differentiating cell. The self-renewal and differentiation of SSCs are precisely regulated as relating the niche of SSCs, glial cell line-derived neurotrophic factor, and several signaling pathways. This article reviews the self-renewal and differentiation of SSCs and their regulation mechanisms, which may offer a deeper insight into spermatogenesis and male infertility and pave a theoretical ground for studying testicular tumorigenesis and searching for new potential approaches to the treatment of testicular cancer and other related diseases.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Spermatogenesis
/
Spermatogonia
/
Cell Differentiation
/
Cells, Cultured
/
Cell Biology
/
Stem Cell Transplantation
/
Adult Stem Cells
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2013
Document type:
Article