Resveratrol improves coronary collateral circulation in pigs with experimental acute coronary occlusion / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 946-949, 2011.
Article
in Zh
| WPRIM
| ID: wpr-268280
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the impact of resveratrol on coronary collateral circulation in pigs suffered from experimental acute coronary occlusion.</p><p><b>METHODS</b>Eighteen healthy pigs were randomly divided into 3 groups: resveratrol group, nitroglycerin group and control group. Animal model of acute coronary occlusion was established through PTCA method, and the blood flow spectrum in the left circumflex artery (LCX) was detected using intracoronary Doppler ultrasound.</p><p><b>RESULTS</b>The average peak velocity (APV) in infarction correlation artery (IRA) was significantly decreased immediately after coronary occlusion [(0.85 ± 0.25) cm/s vs. (24.83 ± 3.43) cm/s, P < 0.05]. The APV remained unchanged during 0, 30 and 60 minutes after the occlusion. Reversed or bidirectional blood flow was observed and the APV increased significantly [(9.22 ± 0.80) cm/s vs. (0.84 ± 0.21) cm/s, (8.93 ± 1.28) cm/s vs. (0.86 ± 0.26) cm/s respectively, P < 0.05] after the coronary injection of resveratrol (2 mg) or nitroglycerin (0.3 mg). There was no significant difference in peak APV between the resveratrol and nitroglycerin groups. The duration of increased APV was significantly longer in resveratrol group than that in nitroglycerin group [(58.83 ± 6.15) min vs. (21.80 ± 5.79) min, P < 0.05].</p><p><b>CONCLUSIONS</b>The collateral circulation after acute coronary occlusion was obviously insufficient in pigs. Resveratrol could significantly improve the blood flow in coronary collateral circulation after acute occlusion in this model.</p>
Full text:
1
Database:
WPRIM
Main subject:
Pharmacology
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Stilbenes
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Swine
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Nitroglycerin
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Collateral Circulation
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Coronary Circulation
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Coronary Vessels
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Disease Models, Animal
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Drug Therapy
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Coronary Occlusion
Limits:
Animals
Language:
Zh
Journal:
Chinese Journal of Cardiology
Year:
2011
Document type:
Article