Evaluation of Amberlite XAD-1600 resin-based purification of the bioactive components from Radix Paeoniae Alba and Rhizoma Curcumae Longae extracts by pharmacodynamic and toxicological models / 南方医科大学学报
Journal of Southern Medical University
; (12): 833-836, 2009.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-268833
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the pharmacodynamics and toxicicity of the major bioactive components extracted and purified from Radix Paeoniae Alba and Rhizoma Curcumae Longae using Amberlite XAD-1600 resin.</p><p><b>METHODS</b>Amberlite XAD-1600 was used to purify the bioactive components from the crude 75% ethanol extracts of the two herbs. The pharmacodynamic and toxic effects of the crude extracts and extract purified using XAD-1600 resin were comparatively examined with two acute inflammatory models, two pain models and acute toxicity test in vivo.</p><p><b>RESULTS</b>The anti-inflammatory and analgesic effects of the purified extract were significant stronger with lower toxicity than those of the crude ethanol extract.</p><p><b>CONCLUSION</b>Amberlite XAD-1600 resin allows efficient extraction and purification of the bioactive components from the two herbs.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Resins, Synthetic
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Drugs, Chinese Herbal
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Chemistry
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Anti-Inflammatory Agents, Non-Steroidal
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Rats, Sprague-Dawley
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Paeonia
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Curcuma
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Toxicity
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Mice, Inbred ICR
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Document type:
Article