HLA-DRB1 allelic polymorphism in children with juvenile idiopathic arthritis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 333-337, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-270347
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the predisposing alleles of HLA-DRB1 genes in Han children with juvenile idiopathic arthritis (JIA) from Guangdong Province, China.</p><p><b>METHODS</b>Polymerase chain reaction-specific sequence primers (PCR-SSP) method was used to type HLA-DRB1 subregions in 94 Han children with JIA and 226 Han healthy controls.</p><p><b>RESULTS</b>The frequency of HLA-DRB1*08 allele in the JIA group was significantly higher than that in the control group (P=0.0014, OR=2.26), in contrast, the frequency of HLA-DRB1*12 allele was significantly lower than that in the control group (P=0.032, OR=0.55). It was found that in children with So-JIA subset (P=0.023, OR=2.25) and polyarthritis JIA subset (P=0.034, OR=2.81), the allele HLA-DRB1*08 was expressed most commonly. The allele HLA-DRB1*15 was expressed in a lower frequency in children with So-JIA subset (P=0.049, OR=0.413) and oligoarthritis subset (P=0.045, OR=0.16) compared with that in the control group.</p><p><b>CONCLUSIONS</b>HLA-DRB1*08 may be the susceptible allele of JIA, while HLA-DRB1*12 may be the protective allele of JIA in Han children from Guangdong Province. HLA-DRB1*08 is the susceptible allele of So-JIA and polyarthrits. HLA-DRB1*15 is the protective allele for systemic JIA and oligoarthritis.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Arthritis, Juvenile
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HLA-DR Antigens
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Genetic Predisposition to Disease
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Alleles
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HLA-DRB1 Chains
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Genetics
Limits:
Adolescent
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Adult
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Aged
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Female
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Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2010
Document type:
Article