Hyponatremia May Reflect Severe Inflammation in Children with Kawasaki Disease
Childhood Kidney Diseases
; : 159-166, 2015.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-27104
Responsible library:
WPRO
ABSTRACT
PURPOSE:
The aim of the present study was to investigate the risk factors for the development of coronary artery lesions (CALs) and to determine whether hyponatremia is associated with CALs in children with Kawasaki disease (KD).METHODS:
We retrospectively analyzed the data of 105 children with KD who were admitted to Ilsan Hospital between January 2000 and July 2011.RESULTS:
Erythrocyte sedimentation rate (P = 0.013), total bilirubin levels (P = 0.017) were higher and serum sodium levels (P = 0.027) were lower in KD children with CALs than those without. White blood cell (WBC) counts (P = 0.006), neutrophil counts (P = 0.003) were higher and albumin levels (P = 0.009) were lower in KD children with hyponatremia than those without. On multiple logistic regression analysis, hyponatremia (P = 0.024) and intravenous immunoglobulin??resistance (P = 0.024) were independent risk factors for CALs in KD. Furthermore, serum sodium levels were correlated negatively with WBC counts (P = 0.004), neutrophil counts (P < 0.001), total bilirubin levels (P = 0.005) and positively with albumin levels (P = 0.009).CONCLUSION:
Our study indicates that hyponatremia may reflect severe inflammation in children with KD.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Sodium
/
Bilirubin
/
Blood Sedimentation
/
Logistic Models
/
Retrospective Studies
/
Risk Factors
/
Cardiovascular Abnormalities
/
Coronary Vessels
/
Hyponatremia
/
Inflammation
Type of study:
Etiology study
/
Observational study
/
Prognostic study
Limits:
Child
/
Humans
Language:
English
Journal:
Childhood Kidney Diseases
Year:
2015
Document type:
Article