Investigation on NB4 cell responses to realgar by cDNA microarray / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 600-604, 2002.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-271863
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To elucidate the molecular mechanism of realgar-induced apoptosis and differentiation of acute promyelocytic leukemia(APL) cell line NB4.</p><p><b>METHOD</b>The response of NB4 cells to realgar was explored with a cDNA microarray representing 1003 different human genes.</p><p><b>RESULT</b>The analysis of gene expression profiles indicated that 9 genes were up-regulated and 37 genes were down-regulated. Among the 9 up-regulated genes, 2 genes were involved in proteasome degradation pathway.</p><p><b>CONCLUSION</b>PSMC2, PSMD1 and ITGB1 genes may play a role in the apoptosis and differentiation of NB4 cells.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Arsenicals
/
Sulfides
/
Materia Medica
/
Tumor Cells, Cultured
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Leukemia, Promyelocytic, Acute
/
Gene Expression Regulation
/
Oligonucleotide Array Sequence Analysis
/
Gene Expression Profiling
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2002
Document type:
Article
