Role of Aberrant Splicing in Pathogenesis of Myelodysplastic Syndromes-Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 617-621, 2017.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-271948
Responsible library:
WPRO
ABSTRACT
The spectrum of genetic abnormalities in myelodysplastic syndromes(MDS) has been revealed by high-throughput sequencing. However, the functional role of these mutations in occurrence and development of MDS was not delineated. The mutations in splicing factors have been identified as the commonest gene mutations in MDS. Recently, it was reported that the mutated or dysregulated splicing factors, including SF3B1, SRSF2 and U2AF1, attribute to aberrant mRNA splicing, which leads to hematopoietic dysfunction and drives MDS. These findings will be of great help in searching for candidate therapeutic targets in mis-splicing pathway in MDS. In this review the role of aberrant splicing in pathogenesis of MDS is summarized briefly.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Prognostic study
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2017
Document type:
Article