Relationship between MnSOD polymorphisms and susceptibility of chronic poisoning exposed to manganism occupationally / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 206-208, 2011.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-272665
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between polymorphisms of MnSOD and the susceptibility of chronic poisoning exposed to manganism occupationally.</p><p><b>METHODS</b>In a study of case-control, genotypes were determined by PCR-RFLP in 164 patients with chronic occupational mangamism poisoning and 328 controls with age- and sex-matched for MnSOD 9Ala-Val.</p><p><b>RESULTS</b>There was a significant difference in the frequency of MnSOD 9Ala-Val at V locus mutant allele between cases and controls (χ(2) = 15.225, P < 0.01, 95%CI = 1.43 ∼ 3.00). Individuals with the genotype VV had a 1.30 of risk increase of occupational chronic manganism poisoning compared with the the genotype AV or AA (OR = 2.30, 95%CI = 1.52 ∼ 3.49, P < 0.05).</p><p><b>CONCLUSION</b>The MnSOD polymorphisms may be related with the susceptibility to chronic occupational manganism poisoning, the risk of chronic occupational manganism poisoning increases in carriers with genotype VV at MnSOD 9Ala-Val locus.</p>
Full text:
Available
Health context:
SDG3 - Target 3.9 Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil
Health problem:
Occupational Exposures
Database:
WPRIM (Western Pacific)
Main subject:
Superoxide Dismutase
/
Case-Control Studies
/
Occupational Exposure
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Genetic Predisposition to Disease
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Manganese Poisoning
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Polymorphism, Single Nucleotide
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Genetics
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Genotype
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Occupational Diseases
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2011
Document type:
Article