Impurity analysis and their structure determination of gatifloxacin / 药学学报
Acta Pharmaceutica Sinica
; (12): 462-464, 2002.
Article
in Zh
| WPRIM
| ID: wpr-274843
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To analyse the impurities of gatifloxacin.</p><p><b>METHODS</b>The impurity of gatifloxacin were analysized and determinated by RP-HPLC/electrospray ionization mass spectrometry with a Zorbax SB-C18(4.6 mm x 150 mm ID, 5 microns). The mobile phase was 3% acetic acid/acetonitrile-3% acetic acid/water (15:85). The two compounds were synthesized: 1-cyclopropyl-6-fluoro-1, 4-dihydro-8-methoxy-7-(1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid (DMP) and 1-cyclopropyl-6-fluoro-1, 4-dihydro-8-hydro-7-(3-methy-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid (DMO). Their liquid chromatogram, UV, MS were compared with those of the impurity of gatifloxacin.</p><p><b>RESULTS</b>The mass of the impurity was 14 less than that of gatifloxacin. It means the impurity was CH2 less than gatifloxacin. The tR (HPLC), UV and MS of DMP were the same as those of the impurity of gatifloxacin.</p><p><b>CONCLUSION</b>Based on the tR (HPLC), UV and MS, the impurity of gatifloxacin is confirmed as DMP.</p>
Full text:
1
Database:
WPRIM
Main subject:
Molecular Structure
/
Chemistry
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Drug Contamination
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Chromatography, High Pressure Liquid
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Spectrometry, Mass, Electrospray Ionization
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Fluoroquinolones
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Anti-Infective Agents
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2002
Document type:
Article