Studies on the chemical constituents from marine brown alga Ishige okamurai (3) / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 269-273, 2002.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-275014
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the chemical constituents of Ishige okamurai.</p><p><b>METHOD</b>Compounds were isolated by Pyricularia oryzae bioassay-guided fractionation method in combination with extraction and partitionation as well as multi-chromatography. Their structures were determined by spectral analysis and chemical evidence.</p><p><b>RESULT</b>Seven compounds were obtained and identified as (2S)-1-O-palmitoyl-2-O-(11Z-octadecenoyl)-3-O-beta-D-galacto-pyranosyl glycerol (I), (2S)-1-O-palmitoyl-2-O-myristoyl-3-O-(6-sulfo-alpha-D- quinovopyranosyl) glycerol (II), (2S)-1-O-palmitoyl-2-O-palmitoyl-3-O-(6'-sulfo-alpha-D- quinovopyranosyl) glycerol (III) and (2S)-1-O-palmitoyl-2-O-(11Z-octadecenoyl)-3-O-(6'-sulfo-alpha-D- quinovopyranosyl) glycerol (IV), stearic acid (V), methyl myristate(VI) and palmitic acid (VII).</p><p><b>CONCLUSION</b>Compounds I-VI were isolated from the alga for the first time while I, II and IV are new natural products. I-IV showed activity causing morphological abnormality of P. oryzae mycelia.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Stearic Acids
/
Tumor Cells, Cultured
/
Glycolipids
/
Molecular Structure
/
Chemistry
/
HL-60 Cells
/
Mitosporic Fungi
/
Phaeophyceae
/
Antineoplastic Agents
Limits:
Female
/
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2002
Document type:
Article