Thoughts and exploration on pharmacokinetic study of herbal medicines based on metabonomics and complex network / 药学学报
Acta Pharmaceutica Sinica
; (12): 558-564, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-276280
Responsible library:
WPRO
ABSTRACT
The change of drug development pattern pushes the innovation of drug valuation methods. The pharmacokinetic research of traditional Chinese medicines (TCM) is an important part of TCM modernization and plays a key role in novel drug development of TCM. However, the research methods and techniques are in consistent with the specific characteristics of TCM, i.e., multiple-components is still in the infant. This review makes a brief summary of current pharmacokinetic exploration of TCM, metabonomics and complex network, and puts forward a new strategy based on complex network and metabonomics to study TCM pharmacokinetic in order to disclose the active components and mechanism of TCM.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Drugs, Chinese Herbal
/
Pharmacokinetics
/
Chemistry
/
Metabolic Networks and Pathways
/
Metabolomics
/
Medicine, Chinese Traditional
Type of study:
Diagnostic study
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Document type:
Article