Relationship between genetic polymorphisms of N-acetyltransferase and susceptibility to hepatocellular carcinoma / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 20-22, 2003.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-276515
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the possible relationship between genetic polymorphism of N-acetyltransferase 2 (NAT2) and susceptibility to hepatocellular carcinoma.</p><p><b>METHODS</b>Genetic polymorphisms of the four NAT2 genes in 78 patients with hepatocellular carcinoma and 112 healthy controls were analyzed by means of real-time fluorescence light-Cycler. The difference in frequencies between the hepatocellular carcinoma patients and the controls were compared.</p><p><b>RESULTS</b>The significant difference in slow acetylation genotype frequency was found between the controls and the hepatocellular carcinoma patients who were smokers (17.9% vs 37.5%, x(2)= 4.67, P<0.05) resulting in increased by 2.76 times the risk for hepatocellular carcinoma, but no evident difference between the controls and hepatocellular carcinoma patients who were non-smokers.</p><p><b>CONCLUSION</b>The smokers with slow acetylation genotype of N-acetyltransferase 2 may be the population with high risk for hepatocellular carcinoma.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Acetylation
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Arylamine N-Acetyltransferase
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Smoking
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Carcinoma, Hepatocellular
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Genetic Predisposition to Disease
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Genetics
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Genotype
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Liver Neoplasms
Limits:
Adult
/
Aged
/
Female
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Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2003
Document type:
Article