Antithymocyte globulin used for treatment of severe acute graft versus host disease after haploidentical bone marrow transplantation / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 816-818, 2007.
Article
in Zh
| WPRIM
| ID: wpr-276816
Responsible library:
WPRO
ABSTRACT
The objective of study was to investigate the effect of low-dose antithymocyte globulin (ATG) on steroid-resistant severe acute graft versus host disease (aGVHD). Six patients with steroid-resistant severe aGVHD after haploidentical bone marrow transplantation (BMT) received the treatment with ATG at a low dose of 1.25 mg/kg for 3 - 5 doses every other day. The results showed that 3 out of 6 patients got completely remission (CR), among them 2 patients have still been in disease-free survival, 1 patient died from leukemia relapse. 1 out of the other 3 patients got partial remissin (PR), 2 patients were aggravated. The other 3 patients all died from GVHD. The major complications observed in these patients were infections. In conclusion, low-dose ATG is effective for some patients with steroid-resistant severe aGVHD, and has not severe side effect. To strengthen environmental protection should be considered as important for prevention of infection.
Full text:
1
Database:
WPRIM
Main subject:
Haplotypes
/
Bone Marrow Transplantation
/
Drug Therapy
/
Allergy and Immunology
/
Graft vs Host Disease
/
HLA Antigens
/
Antilymphocyte Serum
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2007
Document type:
Article