Suppression of gene transcription by polyamide - review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 675-678, 2007.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-276846
Responsible library:
WPRO
ABSTRACT
Polyamide is a synthetic small molecule that recognizes predetermined sequences in the minor groove of DNA with affinities and specificities compared to those of DNA-binding proteins. Polyamide can suppress gene transcription by interfering with the attachment of natural transcription factors and DNA. The alkylating polyamides represent a novel approach for sequence-specific gene silencing, which might be applied to gene therapy. The research on suppression of gene transcription by polyamide was reviewed in this paper.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Transcription, Genetic
/
HIV
/
Gene Silencing
/
Genetics
/
Neoplasms
/
Nylons
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2007
Document type:
Article