Genotyping of HLA-DRB1 by PCR-SSP in Yunnan Lahu ethnic groups / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 389-392, 2002.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-278157
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate polymorphism of HLA-DRB1 in Chinese Lahu population in Yunnan.</p><p><b>METHODS</b>Polymerase chain reaction-sequence specific primers (PCR-SSP) were used to determine HLA-DRB1 genotypes of 110 unrelated healthy Lahu minority people of Yunnan Province.</p><p><b>RESULTS</b>Sixteen alleles of DRB1 were detected in this study. The results of test showed that the genotype distributions observed were corresponded with the Hardy-Weinberg equilibrium.</p><p><b>CONCLUSION</b>This study has obtained a more comprehensive and accurate data set of the normal allele frequencies of HLA-DRB1 in Chinese Lahu population in Yunnan Province, which may be of significance in the studies on population genetics and disease association.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Ethnicity
/
HLA-DR Antigens
/
Polymerase Chain Reaction
/
DNA Primers
/
Asian People
/
HLA-DRB1 Chains
/
Gene Frequency
/
Genetics
/
Genotype
/
Methods
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2002
Document type:
Article