Research advances of hepcidin expression and its regulation mechanism / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1030-1033, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-278442
Responsible library:
WPRO
ABSTRACT
Hepcidin can regulate cell irons' efflux transport. The expression of hepcidin can be influenced by the body signals (such as serum ferritin and erythropoietin levels) as well as inflammation, hypoxia and other disease states. These stimulus activate the signaling pathway of BMP-the SMAD, the JAK-STAT and HIF1 through the liver parenchymal cell surface type I transmembrane glycoprotein of HFE, transferrin receptor 1, 2, hepcidin regulatory proteins, thereby changing the hepcidin gene transcription, regulating the expression levels of hepcidin. However, the molecular mechanism that regulate hepcidin expression is unclear. From the signal factors that affect hepcidin expression and signaling pathways involved in its expression, the latest research progress on regulatory mechanism of hepcidin are summarized.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Signal Transduction
/
Antimicrobial Cationic Peptides
/
Hepcidins
/
Membrane Proteins
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2012
Document type:
Article