Influence of polypeptide extract from scorpion venom on PI3K and p-Akt signaling protein expression and cell proliferation of K562 cells / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 872-875, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-278475
Responsible library:
WPRO
ABSTRACT
This study was aimed to investigate the effect of polypeptide extract from scorpion venom (PESV) on PI3K, p-Akt signal protein regulating K562 cell apoptosis and its mechanism. The K562 cells were cultured with PESV for different time, the cell growth curve was determined by MTT method, the levels of PI3K and p-Akt proteins were detected by Western blot. The results showed that as compared with control group, the apoptosis rate of K562 cells treated with PESV increased, the levels of PI3K and p-Akt expression decreased. It is concluded that the PESV inhibits the proliferation and promotes the apoptosis of K562 cells probably through suppressing the expression of PI3K and p-Akt signal proteins.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Scorpion Venoms
/
Signal Transduction
/
Apoptosis
/
Phosphatidylinositol 3-Kinases
/
K562 Cells
/
Cell Proliferation
/
Proto-Oncogene Proteins c-akt
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2012
Document type:
Article