Effect of angiotensin II on potassium channels of ischemic ventricular myocytes of the guinea pig / 生理学报
Acta Physiologica Sinica
; (6): 149-153, 2002.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-279321
Responsible library:
WPRO
ABSTRACT
The experiments were carried out on guinea pig isolated ventricular myocytes by using whole-cell patch clamp. The effects of angiotensin II (Ang II) on potassium ion channels of acute ischemic myocytes were observed. Whole-cell patch clamp recordings showed that physiological potassium current, including delayed rectifier potassium current and inward rectifier potassium current were inhibited under the condition of simulated ischemia, and then further inhibited by treatment with Ang II. ATP-sensitive potassium currents were increased under simulated ischemia and were further enhanced by Ang II treatment.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Physiology
/
Angiotensin II
/
Potassium Channels
/
Cells, Cultured
/
Myocardial Ischemia
/
Cell Biology
/
Myocytes, Cardiac
/
Guinea Pigs
Limits:
Animals
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2002
Document type:
Article