Mechanism of CD4+CD25+ and CD8+ regulatory T cells--review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1137-1140, 2005.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-280750
Responsible library:
WPRO
ABSTRACT
Regulatory T cells (Treg) play a key role in the negative regulation of the immune system, which can inhibit inappropriate self-reactive T cells, as well as limit the range, extent and lasting time of immune responses, so as to inhibit the proliferation of CD4(+) and CD8(+) effector T cells. In view of these properties, there is little doubt about the enormous potential value of Tregs in molecular mechanisms and clinical treatment of human autoimmune disorders, graft-versus-host disease (GVHD) and allergies. In this review, the molecular mechanisms of CD4(+)CD25(+) Treg and CD8(+) Treg were mainly discussed, and challenge with which study on Treg cells is faced and prospects were briefly described.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Autoimmune Diseases
/
T-Lymphocytes, Regulatory
/
CD8-Positive T-Lymphocytes
/
Allergy and Immunology
/
Interleukin-2 Receptor alpha Subunit
/
Graft vs Host Disease
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2005
Document type:
Article