Mechanism of tau hyperphosphorylation in brain cortex of diabetic rats and effect of LiCl / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 244-248, 2006.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-281223
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the mechanism of tau hyperphosphorylation and the effect of LiCl on tau phosphorylation and the memory retention deficits in streptozotocin-induced diabetes mellitus (DM) rats.</p><p><b>METHODS</b>The rats were randomly divided into control, DM, DM + NaCl, and DM + LiCl groups and diabetes was induced by streptozotocin. The activity of glycogen synthase kinase-3 (GSK-3) was measured by 32P-labelling. The level of tau phosphorylated and changes of memory retention were examined by Western blotting and step down test, respectively.</p><p><b>RESULTS</b>Compared with control group, the activity of GSK-3 and tau phosphorylation was increased, and the memory retention was impaired in DM group. When the rats were treated with LiCl, the activity of GSK-3 and hyperphosphorylation of tau were significantly arrested (P < 0.05, P < 0.01), and the memory retention deficit was significantly improved (P < 0.05).</p><p><b>CONCLUSION</b>The hyperphosphorylation of tau can be induced by activation of GSK-3 in diabetic rats. Lithium protects tau from hyperphosphorylation and may rescue memory retention in the rats by inhibiting GSK-3 activity.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Phosphorylation
/
Cerebral Cortex
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Tau Proteins
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Rats, Sprague-Dawley
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Lithium Chloride
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Glycogen Synthase Kinase 3
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Therapeutic Uses
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Diabetes Mellitus, Experimental
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Drug Therapy
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Memory Disorders
Limits:
Animals
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2006
Document type:
Article