Preparation of gemcitabine polybutylcyanoacrylate nanoparticles / 南方医科大学学报
Journal of Southern Medical University
; (12): 1653-1656, 2007.
Article
in Zh
| WPRIM
| ID: wpr-281570
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To optimize the preparation process of gemcitabine polybutylcyanoacrylate nanoparticles (GCTB- PBCA-NP).</p><p><b>METHODS</b>According to the particle size, the entrapment efficiency and the loading quantity of GCTB-PBCA-NP, single factor analysis was carried out to optimize the component composition and preparation process based on an orthogonal design.</p><p><b>RESULTS</b>The mean particle size of the NP was (112-/+9) nm with an entrapment efficiency of (54.12-/+2.43)% and drug loading of (11.08-/+0.89)%.</p><p><b>CONCLUSION</b>An optimized nanoparticular drug delivery system is obtained by emulsion polymerization.</p>
Full text:
1
Database:
WPRIM
Main subject:
Chemistry
/
Chemistry, Pharmaceutical
/
Drug Delivery Systems
/
Deoxycytidine
/
Enbucrilate
/
Nanoparticles
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2007
Document type:
Article