Preparation and antitussive, expectorant and antiasthmatic activities of verticinone-bile acids salts / 药学学报
Acta Pharmaceutica Sinica
; (12): 274-278, 2007.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-281908
Responsible library:
WPRO
ABSTRACT
To search for potential drugs with potent antitussive, expectorant, antiasthmatic activities and low toxicity, a series of verticinone-bile acids salts were prepared based on the clearly elucidated antitussive, expectorant and antiasthmatic activities of verticinone in bulbs of Fritillaria and different bile acids in Snake Bile. The antitussive, expectorant and antiasthmatic activities of these verticinone-bile acid salts were then screened with different animal models. Ver-CA (verticinone-cholic acid salt) and Ver-CDCA (verticinone-chenodeoxycholic acid salt) showed much more potent activities than other compounds. The bioactivities of Ver-CA and Ver-CDCA are worthy to be intensively studied, and it is also deserved to pay much attention to their much more potent antitussive effects than codeine phosphate. In order to elucidate whether they have synergistic effect and attenuated toxicity, their activities will be continuously compared with single verticinone, cholic acid and chenodeoxycholic acid at the same doses on different animal models. The application of "combination principles" in traditional Chinese medicinal formulations may be a novel way in triditional Chinese medicine research and discovery.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Antitussive Agents
/
Pharmacology
/
Plants, Medicinal
/
Asthma
/
Snakes
/
Bile Acids and Salts
/
Random Allocation
/
Cevanes
/
Chemistry
/
Chenodeoxycholic Acid
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2007
Document type:
Article