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Familial Wolff-Parkinson-White syndrome is linked to the loci on chromosome 7q3 / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 1733-1735, 2002.
Article in English | WPRIM (Western Pacific) | ID: wpr-282100
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Wolff-Parkinson-White syndrome (WPW) is considered to be an autosomal dominant hereditary disease, but the gene is not identified. The objective of this study was to localize the genetic loci of Wolff-Parkinson-White syndrome.</p><p><b>METHODS</b>Linkage analysis between the disease of Wolff-Parkinson-White syndrome and 3 STR (short tandem repeats) markers on 7q3 (D7S505, D7S688, and D7S483) was tested in 3 kindreds of the Wolff-Parkinson-White syndrome (101 numbers in total) by genotyping.</p><p><b>RESULTS</b>Wolff-Parkinson-White syndrome was linked to the loci above. The maximum two-point Lod score detected at D7S505 was 6.4 at a recombination fraction (theta) of 0.1; the Lod score of D7S688, D7S483 was 5.3 vs 2.5.</p><p><b>CONCLUSION</b>The gene of Wolff-Parkinson-White syndrome is located at 7q3.</p>
Subject(s)
Full text: Available Database: WPRIM (Western Pacific) Main subject: Wolff-Parkinson-White Syndrome / Chromosomes, Human, Pair 7 / Genetic Markers / Chromosome Mapping / Tandem Repeat Sequences / Genetics Type of study: Prognostic study Limits: Adolescent / Adult / Child / Female / Humans / Male Language: English Journal: Chinese Medical Journal Year: 2002 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Wolff-Parkinson-White Syndrome / Chromosomes, Human, Pair 7 / Genetic Markers / Chromosome Mapping / Tandem Repeat Sequences / Genetics Type of study: Prognostic study Limits: Adolescent / Adult / Child / Female / Humans / Male Language: English Journal: Chinese Medical Journal Year: 2002 Document type: Article
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