Oncogene ZNF217 amplification on chromosome 20 q in ovarian serous cystadenocarcinoma and its clinical implications / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the amplification of zinc finger protein 217 (ZNF217) gene on chromosome 20 in ovarian cancer and its clinical significance.</p><p><b>METHODS</b>Twenty-three specimens of ovarian carcinoma (11 cases of early stage and 12 advanced stage), 10 specimens of benign ovarian tumors and 7 normal ovaries were examined for ZNF217 gene amplification on chromosome 20 by fluorescence in situ hybridization (FISH).</p><p><b>RESULTS</b>ZNF217 gene amplification was detected in 12 cases of ovarian cancer (52.17%) and 1 case of benign ovarian tumor, but not in normal ovary. ZNF217 amplification was significantly associated with ovarian cancer.</p><p><b>CONCLUSION</b>Oncogene ZNF217 is associated with the tumor stage and poor prognosis of patients with ovarian cancer.</p>