Preliminary study of gene expression profiling in human type I and II endometrial carcinoma / 南方医科大学学报
Journal of Southern Medical University
; (12): 734-737, 2006.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-282930
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study gene expression profiling in human type I and II endometrial carcinoma.</p><p><b>METHODS</b>Six Affymetrix human genome genechips were utilized to investigate the differences in gene expression profiles between type I and II endometrial carcinoma with bioinformatic analysis.</p><p><b>RESULTS</b>Many genes were highly expressed in estrogen-dependent endometrial carcinoma, and some of them were involved in the metabolism and conversion of estrogen, while some others in estrogen regulation. CYP2C9, for instance, was involved in the conversion of estrogen sulfate to 16-hydroxy sulfate metabolite, DDC in estrogen-dependent pathogenesis of endometrial carcinoma possibly by DDC interaction with AR to enhance steroid receptor transcription.</p><p><b>CONCLUSION</b>High expression of these genes in estrogen-dependent endometrial carcinoma may provide insights into their roles in the pathogenesis and prognosis of this malignancy.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Adenocarcinoma
/
Gene Expression Regulation, Neoplastic
/
Classification
/
Endometrial Neoplasms
/
Adenocarcinoma, Clear Cell
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Reverse Transcriptase Polymerase Chain Reaction
/
Gene Expression Profiling
/
Microarray Analysis
/
Genetics
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2006
Document type:
Article