Pathologic diagnosis and differential diagnosis of pulmonary Langerhans' cell histiocytosis / 中华病理学杂志

ABSTRACT

<p><b>OBJECTIVE</b>Morphologic findings of pulmonary Langerhans' cell histiocytosis were analyzed in order to delineate diagnostic features.</p><p><b>METHODS</b>H&E staining and immunohistochemical studies were performed on 7 cases of pulmonary Langerhans' cell histiocytosis.</p><p><b>RESULTS</b>Infiltration by Langerhan's cells was obvious in all 7 cases. Inflammatory cell infiltrates, interstitial fibrosis and focal necrosis may also be seen. The cells expressed S-100 (7/7), CD68 (3/7), and CD1a (5/5).</p><p><b>CONCLUSIONS</b>In case there is radiologic suspicion of Langerhans' cell histiocytosis, pulmonary biopsy is strongly advised for a definitive diagnosis. S-100 and CD1a immunostaining is also helpful in this respect.</p>