Isolated limb hyperthermic perfusion chemotherapy for melanoma of the extremities / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 937-939, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-284254
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of isolated limb hyperthermic perfusion chemotherapy for melanoma of the extremities.</p><p><b>METHODS</b>Limb isolated hyperthermic perfusion chemotherapy was performed in 41 patients with malignant melanoma of the extremities, and then the primary lesions in 24 patients were removed at 14 - 21 days after chemotherapy. Tumor necrosis was examined by pathology.</p><p><b>RESULTS</b>Among the 41 patients, 40 cases were followed up for 6-113 months, and one was lost. There was no local recurrence in those patients. 29 cases were followed up for more than 3 years, and 26 of them were surviving. Forteen cases were followed up for more than five years, among them 9 cases were surviving. The 3-year and 5-year survival rates of the whole group were 95.0% and 70.0%, respectively. The average reduction of the tumor volume was 55.6% after perfusion. The pathological examination showed that tumor necrosis was 90% - 100% (complete response) in 21 cases (87.5%) and 60% - 89% (partial response) in 3 cases (12.5%).</p><p><b>CONCLUSIONS</b>The isolated limb hyperthermic perfusion chemotherapy is an effective treatment of limb malignant melanoma. It can significantly reduce the local recurrence rate, and improve the 5-year survival rate, prognosis and the quality of life of the patients.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Quality of Life
/
Soft Tissue Neoplasms
/
Remission Induction
/
Chemotherapy, Cancer, Regional Perfusion
/
Survival Rate
/
Follow-Up Studies
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Cisplatin
/
Drug Therapy
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Extremities
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Hyperthermia, Induced
Type of study:
Observational study
/
Prognostic study
Aspects:
Patient-preference
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2012
Document type:
Article