Aryl hydrocarbon receptor interacting protein gene and familial isolated pituitary adenomas / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 640-644, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-284316
Responsible library:
WPRO
ABSTRACT
Familial isolated pituitary adenoma (FIPA) is an autosomal dominant disease, characterized by low penetrance, early-onset disease, more invasive tumor growth, as well as somatotroph and lactotroph adenomas in most cases. It has been indicated that the aryl hydrocarbon receptor interacting protein (AIP) gene is a tumor suppressor gene. Many heterozygous mutations have been discovered in AIP in about 20% of FIPA families. However, the exact molecular mechanism by which its disfunction promotes tumorigenesis of pituitary is unclear.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pituitary Neoplasms
/
Intracellular Signaling Peptides and Proteins
/
Growth Hormone-Secreting Pituitary Adenoma
/
Genetics
/
Mutation
Limits:
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2012
Document type:
Article