Research advances in CKLF-like MARVEL transmembrane domain containing member 5 / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 625-628, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-284319
Responsible library:
WPRO
ABSTRACT
CKLF-like MARVEL transmembrane domain containing member(CMTM)is a novel generic family firstly reported by Peking University Center for Human Disease Genomics. CMTM5 belongs to this family and has exhibited tumor-inhibiting activities. It can encode proteins approaching to the transmembrane 4 superfamily(TM4SF). CMTM5 is broadly expressed in normal adult and fetal human tissues, but is undetectable or down-regulated in most carcinoma cell lines and tissues. Restoration of CMTM5 may inhibit the proliferation, migration, and invasion of carcinoma cells. Although the exact mechanism of its anti-tumor activity remains unclear, CMTM5 may be involved in various signaling pathways governing the occurrence and development of tumors. CMTM5 may be a new target in the gene therapies for tumors, while further studies on CMTM5 and its anti-tumor mechanisms are warranted.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Signal Transduction
/
Chemokines
/
Tumor Suppressor Proteins
/
MARVEL Domain-Containing Proteins
/
Genetics
/
Metabolism
/
Neoplasms
Limits:
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2012
Document type:
Article