Correlations of podocyte injury with glucose regulated protein 78 expression and proteinuria in patients with diabetic nephropathy / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 359-363, 2012.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-284369
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the podocyte injury in patients with diabetic nephropathy (DN) and analyze its relationship with glucose regulated protein 78 (GRP78) and proteinuria.</p><p><b>METHODS</b>The clinical data of 48 patients diagnosed as DN by renal biopsy were reviewed. All patients were divided into two groups according to proteinuria (>3.5 g/d, n=31 and 3.5 g/d, n=17). The density of podocytes was illustrated by immunohistochemistry staining of Wilms tumor-1 (WT-1), and the immunofluorescence double-staining results of synaptopodin and GRP78 in podocytes were detected.</p><p><b>RESULTS</b>The podocyte dentistry of urine protein > 3.5 g/d group was significantly lower than that of urine protein>3.5 g/d group urine protein<3.5 g/d group(P=0.003), and it was negatively correlated with proteinuria (P=0.005). The expressions of synaptopodin and GRP78 in podocytes were also negatively correlated with proteinuria (P=0.004 and P=0.001).</p><p><b>CONCLUSION</b>The podocyte injury is aggravated with increased proteinuria in DN patients, along with the decrease of the adaptive ability of endoplasmic reticulum to stress.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Proteinuria
/
Diabetic Nephropathies
/
Podocytes
/
Heat-Shock Proteins
/
Metabolism
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Acta Academiae Medicinae Sinicae
Year:
2012
Document type:
Article