Effect of triptergium wilfordii polyglycosidium on content of Th1 and Th2 in child recurrent nephrotic syndrome / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 441-443, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-284463
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of triptergium wilfordii polyglycosidium on the content of Th1 and Th2 in the treatment child patients of rcurrent nephrotic syndrome.</p><p><b>METHOD</b>Patients were randomized into treatment group and health group. Sixty-one patients in treatment group were treated with triptergium wilfordii polyglycosidium 1 mg x kg(-1) x d(-1) orally tid for 12 weeks. However, patients in health group was not treated with any drugs. Twelve weeks constituted one course of treatment and the content of IL-12, IL-2, TNF-alpha, IL-13, IL-6, IL-4 in peripheral blood was measured before and behind therapy.</p><p><b>RESULT</b>In treatment group, the content of serum cytokines behind therapy was significantly lower than that before therapy, except for IL-12.</p><p><b>CONCLUSION</b>Triptergium wilfordii polyglycosidium could reduce the cytokine level (except for IL-12) of Th1 and Th2, which could lead a therapeutic effect of in the child patients of RNS.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Drugs, Chinese Herbal
/
Chemistry
/
Interleukin-4
/
Interleukin-2
/
Tumor Necrosis Factor-alpha
/
Th2 Cells
/
Th1 Cells
/
Interleukin-13
/
Interleukin-12
Type of study:
Controlled clinical trial
Limits:
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2008
Document type:
Article